The objective was to conduct a meta-analysis of studies of benzene exposure and non-Hodgkin lymphoma (NHL). A total of 8 cohort and 14 case-control studies were analyzed. Meta-analysis of any benzene exposure resulted in a summary relative risk estimate (SRRE) of 1.02 (95% CI: 0.94 to 1.12). The SRRE changed minimally when only data representing the highest level of benzene exposure were analyzed after an a priori data extraction protocol, using cumulative exposure as the optimum metric (SRRE = 1.08, 95% CI: 0.93 to 1.24). Meta-analysis of five studies that reported results for 60 or more ppm-years of cumulative exposure yielded an SRRE of 1.08 (95% CI: 0.36 to 3.24). Similarly, an SRRE of 1.04 (95% CI: 0.96 to 1.12) for each 25 ppm-year increment of benzene exposure was observed. The results from this meta-analysis are not supportive of an independent association between benzene exposure and NHL.
EpidStat Institute provides scientific expertise related to health issues, pharmaceuticals, medical devices, and environmental chemicals. Our target clientele include companies and groups needing expert assistance, evaluation of complex health issues, and assistance with the conduct and interpretation of epidemiological studies.
EpidStat in the News
EpidStat presented their work on adult respiratory syncytial virus (RSV) disease burden in the U.S. at the ISPOR poster session on May 24, 2016 in Washington, DC. Using 15 years of hospitalization data, we found that, while RSV is a less common disease than influenza, it is more severe – more deaths, longer length of stay, and higher cost. RSV in adults has been under diagnosed in the past, but it is becoming increasingly recognized as a serious cause of respiratory disease in adults, especially the elderly.