Mastocytosis is a heterogeneous group of diseases characterized by abnormal proliferation of mast cells. Systemic mastocytosis (SM), in which abnormal mast cells are present in tissues beyond the skin, is divided into seven subcategories with varying degrees of severity and prognosis. Very little is known about the epidemiology of SM and its subcategories. This retrospective cohort study of 548 adults with SM diagnosed 1997–2010 was constructed using linked Danish national health registries. The most common subtype of mastocytosis was indolent SM (including urticaria pigmentosa) (n = 450; 82%), followed by SM with subtype unknown (n = 61; 11%), SM with associated clonal haematological non-mast cell lineage disease (n = 24; 4%), aggressive SM (n = 8; 2%), and mast cell leukaemia (n = 5; 1%). The incidence rate for SM (all subtypes including urticaria pigmentosa) was 089 per 100 000 per year. Cumulative incidence was 1246 per 100 000, and the 14-year limited-duration revalence as of 1 January, 2011 was 959 per 100 000. This nationwide cohort from Denmark is the first population-based epidemiological study of mastocytosis. In this cohort of patients aged 15 years and older, SM was found to be overall relatively rare with notable variation by subtype for patient characteristics, survival and epidemiological measures.
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EpidStat presented their work on adult respiratory syncytial virus (RSV) disease burden in the U.S. at the ISPOR poster session on May 24, 2016 in Washington, DC. Using 15 years of hospitalization data, we found that, while RSV is a less common disease than influenza, it is more severe – more deaths, longer length of stay, and higher cost. RSV in adults has been under diagnosed in the past, but it is becoming increasingly recognized as a serious cause of respiratory disease in adults, especially the elderly.